Reactome | Signaling by Insulin receptor

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Signaling by Insulin receptor Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222221
displayName	Signaling by Insulin receptor
eventOf	[Pathway:R-RNO-9006934] Signaling by Receptor Tyrosine Kinases - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23727] insulin receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-74716] Insulin binds the insulin receptor - Rattus norvegicus [Reaction:R-RNO-74715] Autophosphorylation of insulin receptor - Rattus norvegicus [BlackBoxEvent:R-RNO-74718] Internalisation of the insulin receptor - Rattus norvegicus [Pathway:R-RNO-74751] Insulin receptor signalling cascade - Rattus norvegicus [Pathway:R-RNO-77387] Insulin receptor recycling - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-74752] Signaling by Insulin receptor - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	7
name	Signaling by Insulin receptor Insulin receptor mediated signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-74752
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9006934] Signaling by Receptor Tyrosine Kinases
(hasEncapsulatedEvent)	[Pathway:R-RNO-5673001] RAF/MAP kinase cascade
(inferredTo)	[Pathway:R-HSA-74752] Signaling by Insulin receptor

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