Reactome | Insulin binds the insulin receptor

Schema > Reaction > Entries

Insulin binds the insulin receptor Show undefined attributes

category	binding
compartment	[Compartment:947586] external side of plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10108367
displayName	Insulin binds the insulin receptor
eventOf	[Pathway:R-RNO-74752] Signaling by Insulin receptor - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-74715] Autophosphorylation of insulin receptor - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-74716] Insulin binds the insulin receptor - Homo sapiens
input	[Complex:R-RNO-74674] Insulin [extracellular region] [Complex:R-RNO-74675] Insulin receptor [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Insulin binds the insulin receptor
output	[Complex:R-RNO-74703] Insulin:Insulin receptor [plasma membrane]
precedingEvent	[BlackBoxEvent:R-RNO-74734] Re-integration of insulin receptor into plasma membrane - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-74716
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-74752] Signaling by Insulin receptor
(precedingEvent)	[Reaction:R-RNO-74715] Autophosphorylation of insulin receptor
(inferredTo)	[Reaction:R-HSA-74716] Insulin binds the insulin receptor

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