Reactome | PI3K [cytosol]

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PI3K [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-9699995] Active ALK:PI3K [plasma membrane] - Rattus norvegicus [Complex:R-RNO-9842596] p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] - Rattus norvegicus [Complex:R-RNO-2424456] DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] - Rattus norvegicus
consumedByEvent	[BlackBoxEvent:R-RNO-201515] Active ALK recruits PI3K - Rattus norvegicus [Reaction:R-RNO-204798] Interaction of Tie2 and p85 of PI3K - Rattus norvegicus [Reaction:R-RNO-74737] p-Y-IRS1,p-Y-IRS2 bind PI3K - Rattus norvegicus [Reaction:R-RNO-2730842] PI3K associates with phosphorylated GAB2 - Rattus norvegicus [Reaction:R-RNO-5357479] p-AXL binds PI3K - Rattus norvegicus [Reaction:R-RNO-2029273] PI3K binds to p-6Y-SYK - Rattus norvegicus [Reaction:R-RNO-9842649] Active LTK receptor binds PI3K - Rattus norvegicus [Reaction:R-RNO-2424482] p85 regulatory unit of PI3K binds p-6Y-SYK - Rattus norvegicus [Reaction:R-RNO-9658253] RAS:GTP binds PI3K - Rattus norvegicus [Reaction:R-RNO-202203] Recruitment of PI3K to plasma membrane - Rattus norvegicus [Reaction:R-RNO-186780] PI3-kinase binds to the active receptor - Rattus norvegicus [Reaction:R-RNO-198315] Active IRS recruits PI3K to the plasma membrane and activates it - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10108623
displayName	PI3K [cytosol]
hasComponent	[DefinedSet:R-RNO-74689] PI3K-catalytic subunit [cytosol] [DefinedSet:R-RNO-74688] PI3K-regulatory subunit [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-74693] PI3K [cytosol] - Homo sapiens
maxDepth	3
name	PI3K
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-74693
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[BlackBoxEvent:R-RNO-201515] Active ALK recruits PI3K [Reaction:R-RNO-9842649] Active LTK receptor binds PI3K [Reaction:R-RNO-204798] Interaction of Tie2 and p85 of PI3K [Reaction:R-RNO-2424482] p85 regulatory unit of PI3K binds p-6Y-SYK [Reaction:R-RNO-74737] p-Y-IRS1,p-Y-IRS2 bind PI3K [Reaction:R-RNO-2730842] PI3K associates with phosphorylated GAB2 [Reaction:R-RNO-9658253] RAS:GTP binds PI3K [Reaction:R-RNO-5357479] p-AXL binds PI3K [Reaction:R-RNO-202203] Recruitment of PI3K to plasma membrane [Reaction:R-RNO-186780] PI3-kinase binds to the active receptor [Reaction:R-RNO-2029273] PI3K binds to p-6Y-SYK [Reaction:R-RNO-198315] Active IRS recruits PI3K to the plasma membrane and activates it
(hasComponent)	[Complex:R-RNO-9699995] Active ALK:PI3K [plasma membrane] [Complex:R-RNO-9842596] p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] [Complex:R-RNO-204834] p85 bound to Tie2 [plasma membrane] [Complex:R-RNO-2424456] DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] [Complex:R-RNO-190928] Activated FGFR bound to PI3K [cytosol] [Complex:R-RNO-74694] p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] [Complex:R-RNO-2685700] p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] [Complex:R-RNO-9658249] p21 RAS:GTP:PI3K [plasma membrane] [Complex:R-RNO-5357453] VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] [Complex:R-RNO-5218777] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] [Complex:R-RNO-2029149] PI3K:p-6Y-SYK [plasma membrane] [Complex:R-RNO-213135] Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] [Complex:R-RNO-202283] PI3K bound to TRAT [plasma membrane] [Complex:R-RNO-186789] PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] [Complex:R-RNO-198344] Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane]
(activeUnit)	[CatalystActivity:10153415] 1-phosphatidylinositol-3-kinase activity of PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] [CatalystActivity:10166534] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] [CatalystActivity:10168076] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] [CatalystActivity:10175258] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] [CatalystActivity:10123275] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] [CatalystActivity:10162503] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of PI3K:p-6Y-SYK [plasma membrane]
(inferredTo)	[Complex:R-HSA-74693] PI3K [cytosol]

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