Reactome | Depyrimidination

Schema > Pathway > Entries

Depyrimidination Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222425
displayName	Depyrimidination
eventOf	[Pathway:R-RNO-73929] Base-Excision Repair, AP Site Formation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Pathway:R-RNO-110381] Resolution of AP sites via the single-nucleotide replacement pathway - Rattus norvegicus [Pathway:R-RNO-73930] Abasic sugar-phosphate removal via the single-nucleotide replacement pathway - Rattus norvegicus [Pathway:R-RNO-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway - Rattus norvegicus [Pathway:R-RNO-110362] POLB-Dependent Long Patch Base Excision Repair - Rattus norvegicus [Pathway:R-RNO-110357] Displacement of DNA glycosylase by APEX1 - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:18786] depyrimidination
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-RNO-110328] Recognition and association of DNA glycosylase with site containing an affected pyrimidine - Rattus norvegicus [Pathway:R-RNO-110329] Cleavage of the damaged pyrimidine - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-73928] Depyrimidination - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Depyrimidination
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-73928
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-73929] Base-Excision Repair, AP Site Formation
(precedingEvent)	[Pathway:R-RNO-110381] Resolution of AP sites via the single-nucleotide replacement pathway [Pathway:R-RNO-73930] Abasic sugar-phosphate removal via the single-nucleotide replacement pathway [Pathway:R-RNO-110373] Resolution of AP sites via the multiple-nucleotide patch replacement pathway [Pathway:R-RNO-110362] POLB-Dependent Long Patch Base Excision Repair [Pathway:R-RNO-110357] Displacement of DNA glycosylase by APEX1
(inferredTo)	[Pathway:R-HSA-73928] Depyrimidination

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