Reactome | SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly

Schema > Reaction > Entries

SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly Show undefined attributes

catalystActivity	[CatalystActivity:10105358] aldehyde-lyase activity of SHMT1 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10105360
displayName	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly
eventOf	[Pathway:R-RNO-71262] Carnitine synthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-71260] ALDH9A1 tetramer dehydrogenates TEABL to form TEABT - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-71249] SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly - Homo sapiens
input	[SimpleEntity:R-ALL-31503] HTMLYS [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (3S)-3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine => 4-(trimethylamino)butanal + glycine beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine
output	[SimpleEntity:R-ALL-29424] Gly [cytosol] [SimpleEntity:R-ALL-31311] TEABL [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-71249
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-71262] Carnitine synthesis
(precedingEvent)	[Reaction:R-RNO-71260] ALDH9A1 tetramer dehydrogenates TEABL to form TEABT
(inferredTo)	[Reaction:R-HSA-71249] SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly

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