Reactome | histidine => urocanate + NH4+

Schema > Reaction > Entries

histidine => urocanate + NH4+ Show undefined attributes

catalystActivity	[CatalystActivity:10104955] histidine ammonia-lyase activity of HAL [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10104957
displayName	histidine => urocanate + NH4+
eventOf	[Pathway:R-RNO-70921] Histidine catabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-70903] urocanate + H2O => 4-imidazolone-5-propanoate - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-70899] histidine => urocanate + NH4+ - Homo sapiens
input	[SimpleEntity:R-ALL-29612] L-His [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	histidine => urocanate + NH4+ L-histidine => NH4(+) + trans-urocanate
output	[SimpleEntity:R-ALL-31633] NH4+ [cytosol] [SimpleEntity:R-ALL-30721] UCA [cytosol]
precedingEvent	[Reaction:R-RNO-8932851] PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-70899
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-70921] Histidine catabolism
(precedingEvent)	[Reaction:R-RNO-70903] urocanate + H2O => 4-imidazolone-5-propanoate
(inferredTo)	[Reaction:R-HSA-70899] histidine => urocanate + NH4+

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