Reactome | Cell Cycle Checkpoints

Schema > Pathway > Entries

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10221977
displayName	Cell Cycle Checkpoints
eventOf	[TopLevelPathway:R-RNO-1640170] Cell Cycle - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:18630] cell cycle checkpoint signaling
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-RNO-69615] G1/S DNA Damage Checkpoints - Rattus norvegicus [Pathway:R-RNO-69481] G2/M Checkpoints - Rattus norvegicus [Pathway:R-RNO-69618] Mitotic Spindle Checkpoint - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-69620] Cell Cycle Checkpoints - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	7
name	Cell Cycle Checkpoints
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-69620
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[TopLevelPathway:R-RNO-1640170] Cell Cycle
(hasEncapsulatedEvent)	[Pathway:R-RNO-2559580] Oxidative Stress Induced Senescence [Pathway:R-RNO-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-RNO-2559585] Oncogene Induced Senescence [Pathway:R-RNO-5625740] RHO GTPases activate PKNs
(inferredTo)	[Pathway:R-HSA-69620] Cell Cycle Checkpoints