Reactome | RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles

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RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles Show undefined attributes

category	binding
compartment	[Compartment:263163] trans-Golgi network membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10196619
displayName	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles
eventOf	[Pathway:R-RNO-6811440] Retrograde transport at the Trans-Golgi-Network - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-6814682] Fusion of early-endosome derived vesicles at the TGN - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-6811431] RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles - Homo sapiens
input	[Complex:R-RNO-6814069] AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] [Complex:R-RNO-6814058] COG complex [trans-Golgi network membrane] [Complex:R-RNO-6811301] GARP complex [trans-Golgi network membrane] [Complex:R-RNO-6811353] RAB6:GTP:RIC1:RGP1 [trans-Golgi network membrane] [Complex:R-RNO-6811339] STX6:STX16:VTI1A [trans-Golgi network membrane] [Complex:R-RNO-6811333] VAMP4:early endosome-to-TGN cargo [transport vesicle]
isInDisease	false
isInferred	true
maxDepth	1
name	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles
output	[Complex:R-RNO-6811357] RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane]
precedingEvent	[Reaction:R-RNO-6811429] RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange - Rattus norvegicus
regulatedBy	[PositiveRegulation:10196620] Positive regulation by 'RAB43:GTP [trans-Golgi network membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6811431
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-6811440] Retrograde transport at the Trans-Golgi-Network
(precedingEvent)	[BlackBoxEvent:R-RNO-6814682] Fusion of early-endosome derived vesicles at the TGN
(inferredTo)	[Reaction:R-HSA-6811431] RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles

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