Reactome | RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles

Schema > Reaction > Entries

RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles Show undefined attributes

authored	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
category	binding
compartment	[Compartment:263163] trans-Golgi network membrane
created	[InstanceEdit:6811430] Rothfels, Karen, 2015-11-19
dbId	6811431
displayName	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles
edited	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
eventOf	[Pathway:R-HSA-6811440] Retrograde transport at the Trans-Golgi-Network - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6814682] Fusion of early-endosome derived vesicles at the TGN - Homo sapiens
input	[Complex:R-HSA-6814069] AcG-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:TGN Golgin dimers [trans-Golgi network membrane] [Complex:R-HSA-6814058] COG complex [trans-Golgi network membrane] [Complex:R-HSA-6811301] GARP complex [trans-Golgi network membrane] [Complex:R-HSA-6811353] RAB6:GTP:RIC1:RGP1 [trans-Golgi network membrane] [Complex:R-HSA-6811339] STX6:STX16:VTI1A [trans-Golgi network membrane] [Complex:R-HSA-6811333] VAMP4:early endosome-to-TGN cargo [transport vesicle]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6811204] Characterization of the human GARP (Golgi associated retrograde protein) complex [LiteratureReference:6811268] Transport according to GARP: receiving retrograde cargo at the trans-Golgi network [LiteratureReference:6811243] Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes [LiteratureReference:6811192] A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells [LiteratureReference:6811245] Ric1-Rgp1 complex is a guanine nucleotide exchange factor for the late Golgi Rab6A GTPase and an effector of the medial Golgi Rab33B GTPase [LiteratureReference:6811218] Entry at the trans-face of the Golgi [LiteratureReference:6811200] Are Rab proteins the link between Golgi organization and membrane trafficking? [LiteratureReference:6814826] Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [LiteratureReference:6814823] Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells [LiteratureReference:6811260] Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi [LiteratureReference:6811214] Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network [LiteratureReference:6811198] Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex [LiteratureReference:6811269] Vps51p links the VFT complex to the SNARE Tlg1p [LiteratureReference:6813945] Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform [LiteratureReference:6813974] Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity [LiteratureReference:6811256] The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport [LiteratureReference:6814012] The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers [LiteratureReference:6814020] The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure [LiteratureReference:6813928] A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling [LiteratureReference:6813939] Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network [LiteratureReference:6814021] tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre [LiteratureReference:6813977] Multiple Rab GTPase binding sites in GCC185 suggest a model for vesicle tethering at the trans-Golgi [LiteratureReference:6814006] The golgin coiled-coil proteins of the Golgi apparatus
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles
orthologousEvent	[Reaction:R-GGA-6811431] RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles - Gallus gallus [Reaction:R-BTA-6811431] RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles - Bos taurus [Reaction:R-RNO-6811431] RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles - Rattus norvegicus [Reaction:R-MMU-6811431] RAB6:GTP binds the GARP and COG complexes, t-SNAREs and endosome-derived vesicles - Mus musculus
output	[Complex:R-HSA-6811357] RAB6:GTP:RIC1:RGP1:GARP complex:COG complex:AcM-ARFRP1:GTP:SYS1:MyrG-ARL1:GTP:Golgin dimers:STX6:STX16:VTI1A:VAMP4:early endosome-to-TGN cargo [trans-Golgi network membrane]
precedingEvent	[Reaction:R-HSA-6811429] RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-8847556] Positive regulation by 'RAB43:GTP [trans-Golgi network membrane]'
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855182] Gillespie, Marc E, 2016-02-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6811431
summation	[Summation:6811275] Active RAB6 contributes to the recruitment of the Golgi-asso...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-6814682] Fusion of early-endosome derived vesicles at the TGN
(hasEvent)	[Pathway:R-HSA-6811440] Retrograde transport at the Trans-Golgi-Network

Cite Us!