Reactome | PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA

Schema > Reaction > Entries

PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10196071] trans-2-enoyl-CoA reductase (NADPH) activity of PECR tetramer [peroxisomal membrane]
category	transition
compartment	[Compartment:17947] peroxisomal membrane [Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10196073
displayName	PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA
eventOf	[Pathway:R-RNO-389599] Alpha-oxidation of phytanate - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-389639] phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-6809810] PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA - Homo sapiens
input	[OtherEntity:R-ALL-6809811] 2E-phytenoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-193465] H+ [peroxisomal matrix] [SimpleEntity:R-ALL-113602] NADPH [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA a (2E)-enoyl-CoA + H(+) + NADPH => a 2,3-saturated acyl-CoA + NADP(+)
output	[SimpleEntity:R-ALL-389556] NADP+ [peroxisomal matrix] [SimpleEntity:R-ALL-389615] Phytanoyl-CoA [peroxisomal matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6809810
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-389599] Alpha-oxidation of phytanate
(precedingEvent)	[Reaction:R-RNO-389639] phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2
(inferredTo)	[Reaction:R-HSA-6809810] PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA

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