Reactome | DHCR24 reduces ZYMOL to ZYMSTNL

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DHCR24 reduces ZYMOL to ZYMSTNL Show undefined attributes

catalystActivity	[CatalystActivity:10123114] Delta24-sterol reductase activity of DHCR24 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10195016
displayName	DHCR24 reduces ZYMOL to ZYMSTNL
eventOf	[Pathway:R-RNO-9969901] Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-6807052] EBP isomerizes ZYMSTNL to LTHSOL - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-6807064] DHCR24 reduces ZYMOL to ZYMSTNL - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-194691] ZYMOL [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	DHCR24 reduces ZYMOL to ZYMSTNL zymosterol + NADPH + H(+) => 5alpha-cholest-8-en-3beta-ol + NADP(+)
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-6807048] ZYMSTNL [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-RNO-194632] Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6807064
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9969901] Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)
(precedingEvent)	[Reaction:R-RNO-6807052] EBP isomerizes ZYMSTNL to LTHSOL
(inferredTo)	[Reaction:R-HSA-6807064] DHCR24 reduces ZYMOL to ZYMSTNL

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