Reactome | Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)

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Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) Show undefined attributes

catalystActivity	[CatalystActivity:10122857] 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity of HSD17B7 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122859
displayName	Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)
eventOf	[Pathway:R-RNO-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-195690] Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol - Rattus norvegicus [Reaction:R-RNO-6807064] DHCR24 reduces ZYMOL to ZYMSTNL - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-194632] Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-194661] ZYMONE [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) zymosterone + NADPH + H(+) => zymosterol + NADP(+)
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-194691] ZYMOL [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-RNO-194718] 4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-194632
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway)
(precedingEvent)	[Reaction:R-RNO-195690] Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol [Reaction:R-RNO-6807064] DHCR24 reduces ZYMOL to ZYMSTNL
(inferredTo)	[Reaction:R-HSA-194632] Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)

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