Reactome | CHEK2 phosphorylates TTC5

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CHEK2 phosphorylates TTC5 Show undefined attributes

catalystActivity	[CatalystActivity:10103960] protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10194273
displayName	CHEK2 phosphorylates TTC5
eventOf	[Pathway:R-RNO-6804760] Regulation of TP53 Activity through Methylation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-6804229] JMY, TTC5 and EP300 bind - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-6804266] CHEK2 phosphorylates TTC5 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-6804261] phospho-Ttc5 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CHEK2 phosphorylates TTC5
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-6804259] phospho-Ttc5 [nucleoplasm]
precedingEvent	[Reaction:R-RNO-6804276] ATM phosphorylates TTC5 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6804266
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-6804760] Regulation of TP53 Activity through Methylation
(precedingEvent)	[Reaction:R-RNO-6804229] JMY, TTC5 and EP300 bind
(inferredTo)	[Reaction:R-HSA-6804266] CHEK2 phosphorylates TTC5

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