Reactome | PP2A-PP2R5C dephosphorylates MDM2

Schema > Reaction > Entries

PP2A-PP2R5C dephosphorylates MDM2 Show undefined attributes

catalystActivity	[CatalystActivity:10190053] protein serine/threonine phosphatase activity of PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10190055
displayName	PP2A-PP2R5C dephosphorylates MDM2
eventOf	[Pathway:R-RNO-6804757] Regulation of TP53 Degradation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6792863] PP2A-PP2R5C dephosphorylates MDM2 - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-RNO-6792868] PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PP2A-PP2R5C dephosphorylates MDM2
output	[EntityWithAccessionedSequence:R-RNO-6792489] Ccng1 [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-69486] MDM2 [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-RNO-6792873] PP2A-PPP2R5C [nucleoplasm]
precedingEvent	[Reaction:R-RNO-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6792863
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-6804757] Regulation of TP53 Degradation
(inferredTo)	[Reaction:R-HSA-6792863] PP2A-PP2R5C dephosphorylates MDM2