Reactome | CCNG1 recruits PP2A-PPP2R5C to MDM2

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CCNG1 recruits PP2A-PPP2R5C to MDM2 Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10067447
displayName	CCNG1 recruits PP2A-PPP2R5C to MDM2
eventOf	[Pathway:R-RNO-6804757] Regulation of TP53 Degradation - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-6792863] PP2A-PP2R5C dephosphorylates MDM2 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-6792489] Ccng1 [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-6792862] phospho-Mdm2 [nucleoplasm] [Complex:R-RNO-6792873] PP2A-PPP2R5C [nucleoplasm]
isInDisease	false
isInferred	true
name	CCNG1 recruits PP2A-PPP2R5C to MDM2
output	[Complex:R-RNO-6792868] PPP2A-PPPR5C:CCNG1:(p-T218-MDM2, p-S166-MDM2) [nucleoplasm]
precedingEvent	[Reaction:R-RNO-6793666] MDM2 translocates to the nucleus - Rattus norvegicus [Reaction:R-RNO-6793661] (CDK1,CDK2):CCNA phosphorylates MDM2 at T218 - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6792871
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-6804757] Regulation of TP53 Degradation
(precedingEvent)	[Reaction:R-RNO-6792863] PP2A-PP2R5C dephosphorylates MDM2
(inferredTo)	[Reaction:R-HSA-6792871] CCNG1 recruits PP2A-PPP2R5C to MDM2