Reactome | HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10189212] hydroxymethylglutaryl-CoA lyase activity of HMGCLL1:Mg2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10189214
displayName	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA
eventOf	[Pathway:R-RNO-77111] Synthesis of Ketone Bodies - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6788597] HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA - Homo sapiens
input	[SimpleEntity:R-ALL-191374] bHMG-CoA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA
output	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-29666] ACA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6788597
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-77111] Synthesis of Ketone Bodies
(inferredTo)	[Reaction:R-HSA-6788597] HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA

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