Reactome | HAGH hydrolyses (R)-S-LGSH to GSH and LACT

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HAGH hydrolyses (R)-S-LGSH to GSH and LACT Show undefined attributes

catalystActivity	[CatalystActivity:10188318] hydroxyacylglutathione hydrolase activity of HAGH-2:2xZn2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10188320
displayName	HAGH hydrolyses (R)-S-LGSH to GSH and LACT
eventOf	[Pathway:R-RNO-70268] Pyruvate metabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:172230] methylglyoxal catabolic process
inferredFrom	[Reaction:R-HSA-6783221] HAGH hydrolyses (R)-S-LGSH to GSH and LACT - Homo sapiens
input	[SimpleEntity:R-ALL-5694130] (R)-S-LGSH [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HAGH hydrolyses (R)-S-LGSH to GSH and LACT
output	[SimpleEntity:R-ALL-2564757] (2Fe-2S)(1+) [cytosol] [SimpleEntity:R-ALL-5279872] D-LACT [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-RNO-5694071] GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6783221
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-70268] Pyruvate metabolism
(inferredTo)	[Reaction:R-HSA-6783221] HAGH hydrolyses (R)-S-LGSH to GSH and LACT

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