Reactome | GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH

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GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH Show undefined attributes

catalystActivity	[CatalystActivity:10186574] lactoylglutathione lyase activity of GLO1 dimer:2xZn2+ [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10186576
displayName	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH
eventOf	[Pathway:R-RNO-70268] Pyruvate metabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-6783221] HAGH hydrolyses (R)-S-LGSH to GSH and LACT - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:172230] methylglyoxal catabolic process
inferredFrom	[Reaction:R-HSA-5694071] GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH - Homo sapiens
input	[SimpleEntity:R-ALL-29450] GSH [cytosol] [SimpleEntity:R-ALL-5694074] MGXL [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH GLO1 dimer:2xZn2+ trnasforms glutathione and methylglyoxal to lactoylglutathione
output	[SimpleEntity:R-ALL-5694130] (R)-S-LGSH [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5694071
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-70268] Pyruvate metabolism
(precedingEvent)	[Reaction:R-RNO-6783221] HAGH hydrolyses (R)-S-LGSH to GSH and LACT
(inferredTo)	[Reaction:R-HSA-5694071] GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH

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