Reactome | SYK [cytosol]

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SYK [cytosol] Show undefined attributes

candidateOf	[CandidateSet:R-RNO-912625] FYN-like kinases [cytosol] - Rattus norvegicus
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-508449] IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] - Rattus norvegicus [Complex:R-RNO-429424] Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] - Rattus norvegicus [Complex:R-RNO-429424] Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-5621366] SYK binds to p-Y65,Y76-FCER1G - Rattus norvegicus [Reaction:R-RNO-2029452] Recruitment of SYK to phosphorylated ITAMs - Rattus norvegicus [Reaction:R-RNO-210289] Recruitment of SYK to p-DAP12 - Rattus norvegicus [Reaction:R-RNO-5684801] p-Y7-CLEC1B dimer:PDPN binds SYK - Rattus norvegicus [Reaction:R-RNO-429415] SYK binds to integrin alphaIIb beta3 - Rattus norvegicus [Reaction:R-RNO-429415] SYK binds to integrin alphaIIb beta3 - Rattus norvegicus [Reaction:R-RNO-508292] SYK binds IL2RB - Rattus norvegicus [Reaction:R-RNO-2454240] Recruitment of SYK to p-FCERI gamma subunit - Rattus norvegicus [Reaction:R-RNO-983700] SYK binds the activated BCR - Rattus norvegicus [Reaction:R-RNO-139842] Binding of Syk tyrosine kinase - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10113214
displayName	SYK [cytosol]
endCoordinate	635
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-58268] SYK [cytosol] - Homo sapiens
maxDepth	1
name	SYK Q64725
referenceEntity	[ReferenceGeneProduct:uniprot:Q64725] UniProt:Q64725 Syk
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-58268
startCoordinate	1

Referrals

(input)	[Reaction:R-RNO-5684801] p-Y7-CLEC1B dimer:PDPN binds SYK [Reaction:R-RNO-429415] SYK binds to integrin alphaIIb beta3 [Reaction:R-RNO-508292] SYK binds IL2RB [Reaction:R-RNO-5621366] SYK binds to p-Y65,Y76-FCER1G [Reaction:R-RNO-2454240] Recruitment of SYK to p-FCERI gamma subunit [Reaction:R-RNO-2029452] Recruitment of SYK to phosphorylated ITAMs [Reaction:R-RNO-210289] Recruitment of SYK to p-DAP12 [Reaction:R-RNO-983700] SYK binds the activated BCR [Reaction:R-RNO-139842] Binding of Syk tyrosine kinase
(hasComponent)	[Complex:R-RNO-429424] Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] [Complex:R-RNO-508449] IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] [Complex:R-RNO-5621149] pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] [Complex:R-RNO-2454243] Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] [Complex:R-RNO-2029129] clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] [Complex:R-RNO-210250] DAP12 receptors:p-DAP12:SYK [plasma membrane] [Complex:R-RNO-983693] Antigen:p-BCR:SYK [plasma membrane] [Complex:R-RNO-434911] GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] [Complex:R-RNO-5684799] p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane]
(hasCandidate)	[CandidateSet:R-RNO-912625] FYN-like kinases [cytosol]
(activeUnit)	[CatalystActivity:10166101] protein tyrosine kinase activity of DAP12 receptors:p-DAP12:SYK [plasma membrane] [CatalystActivity:10142294] non-membrane spanning protein tyrosine kinase activity of GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-58268] SYK [cytosol]

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