Reactome | ACSF2 ligates CoA-SH to MCFA

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ACSF2 ligates CoA-SH to MCFA Show undefined attributes

catalystActivity	[CatalystActivity:10187090] long-chain fatty acid-CoA ligase activity of ACSF2 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10187092
displayName	ACSF2 ligates CoA-SH to MCFA
eventOf	[Pathway:R-RNO-77289] Mitochondrial Fatty Acid Beta-Oxidation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8047] acyl-CoA metabolic process
inferredFrom	[Reaction:R-HSA-5696004] ACSF2 ligates CoA-SH to MCFA - Homo sapiens
input	[SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-5690531] MCFA [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	ACSF2 ligates CoA-SH to MCFA a medium-chain fatty acid + ATP + CoA => a medium-chain fatty acyl-CoA + AMP + diphosphate
output	[SimpleEntity:R-ALL-159448] AMP [mitochondrial matrix] [SimpleEntity:R-ALL-5690542] MCFA-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5696004
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-77289] Mitochondrial Fatty Acid Beta-Oxidation
(inferredTo)	[Reaction:R-HSA-5696004] ACSF2 ligates CoA-SH to MCFA

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