Reactome | BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2

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BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10182978
displayName	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2
eventOf	[Pathway:R-RNO-1632852] Macroautophagy - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5679266] Beclin-1 complex translocates to the ER - Rattus norvegicus [Reaction:R-RNO-1632843] AMBRA1 binds DYNLL1,DYNLL2 - Rattus norvegicus [Reaction:R-RNO-5678313] AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5678315] BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2 - Homo sapiens
input	[Complex:R-RNO-5678316] BECN1 complex:p-AMBRA1:DYNLL1,DYNLL2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2
output	[Complex:R-RNO-5676032] BECN1 complex [cytosol] [DefinedSet:R-RNO-2029105] DLCs [cytosol] [EntityWithAccessionedSequence:R-RNO-1632854] phospho-Ambra1 [cytosol]
precedingEvent	[Reaction:R-RNO-1632857] ULK1 phosphorylates AMBRA1:BECN1 complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5678315
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1632852] Macroautophagy
(precedingEvent)	[Reaction:R-RNO-5679266] Beclin-1 complex translocates to the ER [Reaction:R-RNO-1632843] AMBRA1 binds DYNLL1,DYNLL2 [Reaction:R-RNO-5678313] AMBRA1:DYNLL1,DYNLL2 binds BECN1 complex
(inferredTo)	[Reaction:R-HSA-5678315] BECN1 complex, p-AMBRA1 dissociate from DYNLL1,DYNLL2

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