Reactome | 26Sproteasome degrades K48polyUb-NIK

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26Sproteasome degrades K48polyUb-NIK Show undefined attributes

catalystActivity	[CatalystActivity:10103487] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10181917
displayName	26Sproteasome degrades K48polyUb-NIK
eventOf	[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-5668520] 26Sproteasome degrades K48polyUb-NIK - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-5668525] Map3k14 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	26Sproteasome degrades K48polyUb-NIK
precedingEvent	[BlackBoxEvent:R-RNO-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5668520
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway
(inferredTo)	[BlackBoxEvent:R-HSA-5668520] 26Sproteasome degrades K48polyUb-NIK

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