Reactome | Translesion synthesis by POLI

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Translesion synthesis by POLI Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224787
displayName	Translesion synthesis by POLI
eventOf	[Pathway:R-RNO-110313] Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:10327] error-prone translesion synthesis
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-5656105] POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA - Rattus norvegicus [Reaction:R-RNO-5656148] POLI incorporates dNMP opposite to damaged DNA base - Rattus norvegicus [Reaction:R-RNO-5656158] POLZ elongates POLI-incorporated dNMP - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-5656121] Translesion synthesis by POLI - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Translesion synthesis by POLI
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5656121
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-110313] Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
(inferredTo)	[Pathway:R-HSA-5656121] Translesion synthesis by POLI