Reactome | Translesion synthesis by POLI

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Translesion synthesis by POLI Show undefined attributes

authored	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5656087] Orlic-Milacic, Marija, 2014-12-10
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220
dbId	5656121
deleted	[Deleted:5676176] Deletion of instance: 110325
displayName	Translesion synthesis by POLI
edited	[InstanceEdit:5656172] Orlic-Milacic, Marija, 2014-12-11
eventOf	[Pathway:R-HSA-110313] Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:10327] error-prone translesion synthesis
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5656105] POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA - Homo sapiens [Reaction:R-HSA-5656148] POLI incorporates dNMP opposite to damaged DNA base - Homo sapiens [Reaction:R-HSA-5656158] POLZ elongates POLI-incorporated dNMP - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5656129] Hoogsteen base pair formation promotes synthesis opposite the 1,N6-ethenodeoxyadenosine lesion by human DNA polymerase iota [LiteratureReference:5656159] Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing [LiteratureReference:5656100] Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis [LiteratureReference:5656099] Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1 [LiteratureReference:5656095] A single domain in human DNA polymerase iota mediates interaction with PCNA: implications for translesion DNA synthesis [LiteratureReference:5656098] Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts [LiteratureReference:5656109] Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis [LiteratureReference:5656120] Interaction of hREV1 with three human Y-family DNA polymerases [LiteratureReference:5656089] Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions [LiteratureReference:5652156] Structural insights into the assembly of human translesion polymerase complexes
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Translesion synthesis by POLI
orthologousEvent	[Pathway:R-PFA-5656121] Translesion synthesis by POLI - Plasmodium falciparum [Pathway:R-SPO-5656121] Translesion synthesis by POLI - Schizosaccharomyces pombe [Pathway:R-DME-5656121] Translesion synthesis by POLI - Drosophila melanogaster [Pathway:R-GGA-5656121] Translesion synthesis by POLI - Gallus gallus [Pathway:R-XTR-5656121] Translesion synthesis by POLI - Xenopus tropicalis [Pathway:R-DRE-5656121] Translesion synthesis by POLI - Danio rerio [Pathway:R-SSC-5656121] Translesion synthesis by POLI - Sus scrofa [Pathway:R-BTA-5656121] Translesion synthesis by POLI - Bos taurus [Pathway:R-CFA-5656121] Translesion synthesis by POLI - Canis familiaris [Pathway:R-RNO-5656121] Translesion synthesis by POLI - Rattus norvegicus [Pathway:R-MMU-5656121] Translesion synthesis by POLI - Mus musculus
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5663080] Borowiec, James, 2015-01-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-5656121
summation	[Summation:5656276] DNA polymerase iota (POLI) is a Y family DNA polymerase with...

Referrals

(replacementInstances)	[Deleted:5676176] Deletion of instance: 110325
(hasEvent)	[Pathway:R-HSA-110313] Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

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