Reactome | UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA

Schema > Reaction > Entries

UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA Show undefined attributes

catalystActivity	[CatalystActivity:10180623] ISG15 transferase activity of UBE2L6:TRIM25:DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10180625
displayName	UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA
eventOf	[Pathway:R-RNO-5656169] Termination of translesion DNA synthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5653766] USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5653754] UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA - Homo sapiens
input	2 × [Complex:R-RNO-5653757] ISG15:UBA7 [nucleoplasm] [Complex:R-RNO-5653760] UBE2L6:TRIM25:DNA polymerase Y:MonoUb:K164-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA
output	[Complex:R-RNO-5653761] DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-RNO-5653762] Uba7 [nucleoplasm] [Complex:R-RNO-5653664] UBE2L6:TRIM25 [nucleoplasm]
precedingEvent	[Reaction:R-RNO-5653756] TRIM25 binds monoUb:164-PCNA - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5653754
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5656169] Termination of translesion DNA synthesis
(precedingEvent)	[Reaction:R-RNO-5653766] USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA
(inferredTo)	[Reaction:R-HSA-5653754] UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA