Reactome | NEIL1,NEIL2 incises DNA strand 5' to the AP site

Schema > Reaction > Entries

NEIL1,NEIL2 incises DNA strand 5' to the AP site Show undefined attributes

catalystActivity	[CatalystActivity:10180375] DNA-(apurinic or apyrimidinic site) endonuclease activity of NEIL1,NEIL2:AP-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10180377
displayName	NEIL1,NEIL2 incises DNA strand 5' to the AP site
eventOf	[Pathway:R-RNO-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5649708] NEIL1,NEIL2 recruits POLB to incised AP site - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5649711] NEIL1,NEIL2 incises DNA strand 5' to the AP site - Homo sapiens
input	[Complex:R-RNO-5649693] NEIL1,NEIL2:AP-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NEIL1,NEIL2 incises DNA strand 5' to the AP site
output	[Complex:R-RNO-5649706] NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-RNO-5649658] NEIL1 cleaves DHU from damaged DNA - Rattus norvegicus [Reaction:R-RNO-5649673] NEIL1 cleaves FapyA from damaged DNA - Rattus norvegicus [Reaction:R-RNO-5649664] NEIL1 cleaves FapyG from damaged DNA - Rattus norvegicus [Reaction:R-RNO-5649701] NEIL1,NEIL2 displace OGG1 from AP-dsDNA - Rattus norvegicus [Reaction:R-RNO-5649681] NEIL2 cleaves 5-OHU from damaged DNA - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5649711
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
(precedingEvent)	[Reaction:R-RNO-5649708] NEIL1,NEIL2 recruits POLB to incised AP site
(inferredTo)	[Reaction:R-HSA-5649711] NEIL1,NEIL2 incises DNA strand 5' to the AP site