Reactome | NEIL1 cleaves FapyA from damaged DNA

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NEIL1 cleaves FapyA from damaged DNA Show undefined attributes

catalystActivity	[CatalystActivity:10180332] DNA N-glycosylase activity of NEIL1:FapyA-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10180334
displayName	NEIL1 cleaves FapyA from damaged DNA
eventOf	[Pathway:R-RNO-110329] Cleavage of the damaged pyrimidine - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5649711] NEIL1,NEIL2 incises DNA strand 5' to the AP site - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5649673] NEIL1 cleaves FapyA from damaged DNA - Homo sapiens
input	[Complex:R-RNO-5649670] NEIL1:FapyA-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NEIL1 cleaves FapyA from damaged DNA
output	[SimpleEntity:R-ALL-5637659] FapyA [nucleoplasm] [Complex:R-RNO-5649669] NEIL1:AP-dsDNA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5649673
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-5649711] NEIL1,NEIL2 incises DNA strand 5' to the AP site
(hasEvent)	[Pathway:R-RNO-110329] Cleavage of the damaged pyrimidine
(inferredTo)	[Reaction:R-HSA-5649673] NEIL1 cleaves FapyA from damaged DNA

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