Reactome | ATP hydrolysis by HSP90

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ATP hydrolysis by HSP90 Show undefined attributes

catalystActivity	[CatalystActivity:10178789] ATP hydrolysis activity of HSP90 complexes [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10178791
displayName	ATP hydrolysis by HSP90
eventOf	[Pathway:R-RNO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-5618093] ATP hydrolysis by HSP90 - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [DefinedSet:R-RNO-9690535] HSP90 complexes [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	ATP hydrolysis by HSP90
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-5324621] Fkbp4 [nucleoplasm] [DefinedSet:R-RNO-5082395] HSP90:HSP90 [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-RNO-5082403] Ptges3 [nucleoplasm] [DefinedSet:R-RNO-5618077] SHR:SH [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-RNO-5618080] HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus - Rattus norvegicus
regulatedBy	[PositiveRegulation:R-HSA-5618100] Positive regulation by 'SH [cytosol]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5618093
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
(inferredTo)	[BlackBoxEvent:R-HSA-5618093] ATP hydrolysis by HSP90