Reactome | MLH1:PMS2 makes single strand incision near 1-2 base mismatch

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MLH1:PMS2 makes single strand incision near 1-2 base mismatch Show undefined attributes

catalystActivity	[CatalystActivity:10176737] endonuclease activity of MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10176739
displayName	MLH1:PMS2 makes single strand incision near 1-2 base mismatch
eventOf	[Pathway:R-RNO-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5358597] EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch - Homo sapiens
input	[Complex:R-RNO-5358511] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	MLH1:PMS2 makes single strand incision near 1-2 base mismatch
output	[Complex:R-RNO-5358528] MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]
precedingEvent	[Reaction:R-RNO-5358510] MSH2:MSH6 recruits MLH1:PMS2 to mismatch and interacts with PCNA - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5358518
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
(precedingEvent)	[Reaction:R-RNO-5358597] EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha)
(inferredTo)	[Reaction:R-HSA-5358518] MLH1:PMS2 makes single strand incision near 1-2 base mismatch

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