Reactome | p38 MAPK activation by VEGFR

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p38 MAPK activation by VEGFR Show undefined attributes

catalystActivity	[CatalystActivity:10052745] MAP kinase kinase activity of VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10052747
displayName	p38 MAPK activation by VEGFR
eventOf	[Pathway:R-RNO-4420097] VEGFA-VEGFR2 Pathway - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-187688] p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-5218804] p38 MAPK activation by VEGFR - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-189828] MAP kinase p38 (Mg2+ cofactor) [cytosol]
isInDisease	false
isInferred	true
name	p38 MAPK activation by VEGFR
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-170993] Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol]
precedingEvent	[Reaction:R-RNO-5218812] FYN phosphorylates PAK2 - Rattus norvegicus
releaseDate	2024-03-27
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5218804
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-RNO-187688] p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3
(inferredTo)	[BlackBoxEvent:R-HSA-5218804] p38 MAPK activation by VEGFR