Reactome | p38 MAPK activation by VEGFR

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p38 MAPK activation by VEGFR Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
catalystActivity	[CatalystActivity:5218808] MAP kinase kinase activity of VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:5218840] Garapati, P V, 2013-12-19
dbId	5218804
displayName	p38 MAPK activation by VEGFR
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway - Homo sapiens
followingEvent	[Reaction:R-HSA-187688] p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-189828] MAP kinase p38 (Mg2+ cofactor) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5218345] p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells [LiteratureReference:5218554] Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	p38 MAPK activation by VEGFR
orthologousEvent	[BlackBoxEvent:R-DRE-5218804] p38 MAPK activation by VEGFR - Danio rerio [BlackBoxEvent:R-CEL-5218804] p38 MAPK activation by VEGFR - Caenorhabditis elegans [BlackBoxEvent:R-GGA-5218804] p38 MAPK activation by VEGFR - Gallus gallus [BlackBoxEvent:R-XTR-5218804] p38 MAPK activation by VEGFR - Xenopus tropicalis [BlackBoxEvent:R-SSC-5218804] p38 MAPK activation by VEGFR - Sus scrofa [BlackBoxEvent:R-BTA-5218804] p38 MAPK activation by VEGFR - Bos taurus [BlackBoxEvent:R-CFA-5218804] p38 MAPK activation by VEGFR - Canis familiaris [BlackBoxEvent:R-RNO-5218804] p38 MAPK activation by VEGFR - Rattus norvegicus [BlackBoxEvent:R-MMU-5218804] p38 MAPK activation by VEGFR - Mus musculus
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-170993] Phospho-MAP kinase p38 (Mg2+ cofactor) [cytosol]
precedingEvent	[Reaction:R-HSA-5218812] FYN phosphorylates PAK2 - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5432673] Welsh, Michael, Berger, Philipp, Ballmer-Hofer, Kurt, 2014-05-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5218804
summation	[Summation:5218548] In primary cultured human umbilical vein endothelial cells (...

Referrals

(hasEvent)	[Pathway:R-HSA-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-HSA-187688] p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3