Reactome | GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

Schema > Reaction > Entries

GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) Show undefined attributes

catalystActivity	[CatalystActivity:10143282] GMP reductase activity of GMPR tetramers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10143284
displayName	GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)
eventOf	[Pathway:R-RNO-74217] Purine salvage - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-514604] GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) - Homo sapiens
input	[SimpleEntity:R-ALL-113578] GMP [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2) GMP + NADPH + 2 H(+) => IMP + NH4(+) + NADP(+)
output	[SimpleEntity:R-ALL-29602] IMP [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol]
precedingEvent	[Reaction:R-RNO-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-514604
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-74217] Purine salvage
(inferredTo)	[Reaction:R-HSA-514604] GMP + NADPH + 2 H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

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