Reactome | Nonendonucleolytic RISC binds exactly matching target RNAs

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Nonendonucleolytic RISC binds exactly matching target RNAs Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10138263
displayName	Nonendonucleolytic RISC binds exactly matching target RNAs
eventOf	[Pathway:R-RNO-426496] Post-transcriptional silencing by small RNAs - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-426522] Nonendonucleolytic RISC binds exactly matching target RNAs - Homo sapiens
input	[DefinedSet:R-RNO-210807] Nonendonucleolytic RISC [cytosol] [OtherEntity:R-ALL-426523] RNA (exact match) [cytosol] [DefinedSet:R-RNO-427775] TNRC6 (GW182) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Nonendonucleolytic RISC binds exactly matching target RNAs
output	[Complex:R-RNO-426510] TNRC6:Nonendonucleolytic RISC:Target RNA (exact match) [cytosol]
precedingEvent	[Reaction:R-RNO-426464] Dicer cleaves double-stranded RNA to yield double-stranded siRNA - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-426522
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-426496] Post-transcriptional silencing by small RNAs
(inferredTo)	[Reaction:R-HSA-426522] Nonendonucleolytic RISC binds exactly matching target RNAs

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