Reactome | EFNB:GRB4 binds GIT1

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10172282
displayName	EFNB:GRB4 binds GIT1
eventOf	[Pathway:R-RNO-3928664] Ephrin signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-3928631] GIT1 binds bPIX - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-3928614] EFNB:GRB4 binds GIT1 - Homo sapiens
input	[Complex:R-RNO-3928522] EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] [EntityWithAccessionedSequence:R-RNO-3928463] phospho-Git1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	EFNB:GRB4 binds GIT1
output	[Complex:R-RNO-3928559] EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3928614
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-3928664] Ephrin signaling
(precedingEvent)	[Reaction:R-RNO-3928631] GIT1 binds bPIX
(inferredTo)	[Reaction:R-HSA-3928614] EFNB:GRB4 binds GIT1

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