Reactome | Release of docked serotonin loaded synaptic vesicle

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Release of docked serotonin loaded synaptic vesicle Show undefined attributes

catalystActivity	[CatalystActivity:10133739] SNARE binding activity of Docked serotonin loaded synaptic vesicle [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:374940] clathrin-sculpted monoamine transport vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10133741
displayName	Release of docked serotonin loaded synaptic vesicle
eventOf	[Pathway:R-RNO-181429] Serotonin Neurotransmitter Release Cycle - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9693347] HTR1A binds 5HT - Rattus norvegicus [Reaction:R-RNO-390929] HTR1 and 5A receptors can bind serotonin - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-380901] Release of docked serotonin loaded synaptic vesicle - Homo sapiens
input	[Complex:R-RNO-380900] Docked serotonin loaded synaptic vesicle [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Release of docked serotonin loaded synaptic vesicle
output	[SimpleEntity:R-ALL-114523] 5HT [extracellular region] [EntityWithAccessionedSequence:R-RNO-210385] Cplx1 [cytosol] [EntityWithAccessionedSequence:R-RNO-210461] RAB3A [plasma membrane] [Complex:R-RNO-210374] RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] [EntityWithAccessionedSequence:R-RNO-374907] SLC18A2 [plasma membrane] [Complex:R-RNO-210441] SNARE complex [plasma membrane] [EntityWithAccessionedSequence:R-RNO-6794254] Stxbp1 [cytosol] [CandidateSet:R-RNO-380576] Synapsin [clathrin-sculpted monoamine transport vesicle membrane] [EntityWithAccessionedSequence:R-RNO-168786] SYT1 [plasma membrane]
precedingEvent	[Reaction:R-RNO-380905] Serotonin loaded synaptic vesicle docking and priming - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-380901
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-181429] Serotonin Neurotransmitter Release Cycle
(precedingEvent)	[Reaction:R-RNO-9693347] HTR1A binds 5HT [Reaction:R-RNO-390929] HTR1 and 5A receptors can bind serotonin
(inferredTo)	[Reaction:R-HSA-380901] Release of docked serotonin loaded synaptic vesicle