Reactome | Serotonin clearance from the synaptic cleft

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Serotonin clearance from the synaptic cleft Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222617
displayName	Serotonin clearance from the synaptic cleft
eventOf	[Pathway:R-RNO-112311] Neurotransmitter clearance - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-444008] SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol - Rattus norvegicus [Reaction:R-RNO-9714415] SLC6A4 binds TCAs and SSRIs - Rattus norvegicus [Pathway:R-RNO-380612] Metabolism of serotonin - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-380615] Serotonin clearance from the synaptic cleft - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Serotonin clearance from the synaptic cleft Clearance of seratonin Clearance of serotonin
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-380615
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-112311] Neurotransmitter clearance
(inferredTo)	[Pathway:R-HSA-380615] Serotonin clearance from the synaptic cleft

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