Reactome | Metabolism of serotonin

Schema > Pathway > Entries

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222615
displayName	Metabolism of serotonin
eventOf	[Pathway:R-RNO-380615] Serotonin clearance from the synaptic cleft - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:12116] serotonin catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-141186] MAOA:FAD oxidatively deaminates of 5HT - Rattus norvegicus [Reaction:R-RNO-380608] 5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-380612] Metabolism of serotonin - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Metabolism of serotonin Metabolism of seratonin
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-380612
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-380615] Serotonin clearance from the synaptic cleft
(inferredTo)	[Pathway:R-HSA-380612] Metabolism of serotonin

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