Reactome | Release of noradrenaline at the synapse

Schema > Reaction > Entries

Release of noradrenaline at the synapse Show undefined attributes

catalystActivity	[CatalystActivity:10130961] SNARE binding activity of Docked Noradrenalin loaded synaptic vesicle [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10130963
displayName	Release of noradrenaline at the synapse
eventOf	[Pathway:R-RNO-181430] Norepinephrine Neurotransmitter Release Cycle - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-374896] Uptake of Noradrenaline - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-374899] Release of noradrenaline at the synapse - Homo sapiens
input	[Complex:R-RNO-374939] Docked Noradrenalin loaded synaptic vesicle [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Release of noradrenaline at the synapse
output	[EntityWithAccessionedSequence:R-RNO-210385] Cplx1 [cytosol] [SimpleEntity:R-ALL-374935] NAd [extracellular region] [EntityWithAccessionedSequence:R-RNO-210461] RAB3A [plasma membrane] [Complex:R-RNO-210374] RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] [EntityWithAccessionedSequence:R-RNO-374907] SLC18A2 [plasma membrane] [Complex:R-RNO-210441] SNARE complex [plasma membrane] [EntityWithAccessionedSequence:R-RNO-6794254] Stxbp1 [cytosol] [EntityWithAccessionedSequence:R-RNO-168786] SYT1 [plasma membrane]
precedingEvent	[Reaction:R-RNO-374922] Noradrenalin synaptic vesicle docking and priming - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-374899
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-181430] Norepinephrine Neurotransmitter Release Cycle
(precedingEvent)	[Reaction:R-RNO-374896] Uptake of Noradrenaline
(inferredTo)	[Reaction:R-HSA-374899] Release of noradrenaline at the synapse