Reactome | 26S proteosome degrades ODC holoenzyme complex

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26S proteosome degrades ODC holoenzyme complex Show undefined attributes

catalystActivity	[CatalystActivity:10103487] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10129980
displayName	26S proteosome degrades ODC holoenzyme complex
eventOf	[Pathway:R-RNO-350562] Regulation of ornithine decarboxylase (ODC) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-350567] Antizyme OAZ binds to Ornithine decarboxylase - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:260545] proteasomal ubiquitin-independent protein catabolic process
inferredFrom	[BlackBoxEvent:R-HSA-353125] 26S proteosome degrades ODC holoenzyme complex - Homo sapiens
input	[Complex:R-RNO-353118] ODC:OAZ complex [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	26S proteosome degrades ODC holoenzyme complex
output	[DefinedSet:R-RNO-350592] OAZ [cytosol]
precedingEvent	[Reaction:R-RNO-350567] Antizyme OAZ binds to Ornithine decarboxylase - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-353125
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-350562] Regulation of ornithine decarboxylase (ODC)
(inferredTo)	[BlackBoxEvent:R-HSA-353125] 26S proteosome degrades ODC holoenzyme complex
(precedingEvent)	[Reaction:R-RNO-350567] Antizyme OAZ binds to Ornithine decarboxylase

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