Reactome | SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine

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SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine Show undefined attributes

catalystActivity	[CatalystActivity:10129906] amino acid transmembrane transporter activity of SLC38A3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10129908
displayName	SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine
eventOf	[Pathway:R-RNO-352230] Amino acid transport across the plasma membrane - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-352174] SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [DefinedSet:R-ALL-352186] ligands of SLC38A3 [extracellular region] 2 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine
output	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [DefinedSet:R-ALL-352169] ligands of SLC38A3 [cytosol] 2 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
precedingEvent	[Reaction:R-RNO-352364] SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-352174
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-352230] Amino acid transport across the plasma membrane
(inferredTo)	[Reaction:R-HSA-352174] SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine

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