Reactome | FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling

Schema > Reaction > Entries

FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10171080
displayName	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
eventOf	[Pathway:R-RNO-3371378] Regulation by c-FLIP - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-3465448] Caspase-8 and FLIP(L) processing at DISC - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-3371356] Cflar [cytosol] [Complex:R-RNO-75114] FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling
output	[Complex:R-RNO-3465499] FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane]
precedingEvent	[Reaction:R-RNO-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3465459
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3371378] Regulation by c-FLIP
(precedingEvent)	[BlackBoxEvent:R-RNO-3465448] Caspase-8 and FLIP(L) processing at DISC
(inferredTo)	[Reaction:R-HSA-3465459] FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling

Cite Us!