Reactome | GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

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GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ Show undefined attributes

catalystActivity	[CatalystActivity:10170742] glutathione-disulfide reductase (NADPH) activity of GSR dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10170744
displayName	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
eventOf	[Pathway:R-RNO-3299685] Detoxification of Reactive Oxygen Species - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3323079] GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Homo sapiens
input	[SimpleEntity:R-ALL-1655882] GSSG [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
output	2 × [SimpleEntity:R-ALL-1655887] GSH [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent	[Reaction:R-RNO-3323013] GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3323079
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3299685] Detoxification of Reactive Oxygen Species
(inferredTo)	[Reaction:R-HSA-3323079] GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

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