Reactome | WNT ligand biogenesis and trafficking

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WNT ligand biogenesis and trafficking Show undefined attributes

created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	10097345
displayName	WNT ligand biogenesis and trafficking
eventOf	[Pathway:R-RNO-195721] Signaling by WNT - Rattus norvegicus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-RNO-3247837] WNT ligands traffic to the Golgi - Rattus norvegicus [Reaction:R-RNO-3247840] WLS binds WNT ligands in the Golgi - Rattus norvegicus [BlackBoxEvent:R-RNO-3247844] WNT ligands traffic to the plasma membrane - Rattus norvegicus [BlackBoxEvent:R-RNO-3781943] WLS:WNT complex is internalized for maturation into exosomes - Rattus norvegicus [BlackBoxEvent:R-RNO-3781941] WNTs are secreted in exosomes - Rattus norvegicus [Reaction:R-RNO-3247843] secretion of WNT ligands - Rattus norvegicus [BlackBoxEvent:R-RNO-3247847] WLS is endocytosed to the early endosome - Rattus norvegicus [Reaction:R-RNO-3247839] Retromer associates with WLS - Rattus norvegicus [BlackBoxEvent:R-RNO-3247836] Retromer recycles WLS to the Golgi - Rattus norvegicus [BlackBoxEvent:R-RNO-3247849] WLS dissociates from retromer - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking - Homo sapiens
isInDisease	false
isInferred	true
name	WNT ligand biogenesis and trafficking
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3238698
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-195721] Signaling by WNT
(hasEncapsulatedEvent)	[Pathway:R-RNO-201681] TCF dependent signaling in response to WNT
(inferredTo)	[Pathway:R-HSA-3238698] WNT ligand biogenesis and trafficking

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