Reactome | AKT:PIP3 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-RNO-199453] AKT:PIP3:THEM4/TRIB3 [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Rattus norvegicus [Reaction:R-RNO-198640] mTORC2 phosphorylates AKT at S473 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10123376
displayName	AKT:PIP3 [plasma membrane]
hasComponent	[CandidateSet:R-RNO-202052] AKT [plasma membrane] [SimpleEntity:R-ALL-179838] PI(3,4,5)P3 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-2317329] AKT:PIP3 [plasma membrane] - Homo sapiens
maxDepth	3
name	AKT:PIP3
producedByEvent	[Reaction:R-RNO-2317332] PIP3 recruits AKT to the membrane - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2317329
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-RNO-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation [Reaction:R-RNO-198640] mTORC2 phosphorylates AKT at S473
(output)	[Reaction:R-RNO-2317332] PIP3 recruits AKT to the membrane
(hasComponent)	[Complex:R-RNO-199453] AKT:PIP3:THEM4/TRIB3 [plasma membrane]
(inferredTo)	[Complex:R-HSA-2317329] AKT:PIP3 [plasma membrane]