Reactome | THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

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THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10124227
displayName	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
eventOf	[Pathway:R-RNO-199418] Negative regulation of the PI3K/AKT network - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:263612] negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferredFrom	[Reaction:R-HSA-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation - Homo sapiens
input	[Complex:R-RNO-2317329] AKT:PIP3 [plasma membrane] [DefinedSet:R-RNO-2400007] THEM4/TRIB3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
output	[Complex:R-RNO-199453] AKT:PIP3:THEM4/TRIB3 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-199443
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-199418] Negative regulation of the PI3K/AKT network
(inferredTo)	[Reaction:R-HSA-199443] THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation

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