Reactome | Interaction of invariant chain trimer and MHC II alpha beta dimer

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Interaction of invariant chain trimer and MHC II alpha beta dimer Show undefined attributes

category	binding
compartment	[Compartment:5263265] lumenal side of endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10163848
displayName	Interaction of invariant chain trimer and MHC II alpha beta dimer
eventOf	[Pathway:R-RNO-2132295] MHC class II antigen presentation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2213241] Formation of nonameric complex - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-195906] CANX [endoplasmic reticulum lumen] [Complex:R-RNO-2130599] Invariant chain trimer [lumenal side of endoplasmic reticulum membrane] [Complex:R-RNO-2213186] MHC II alpha beta heterodimer [lumenal side of endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Interaction of invariant chain trimer and MHC II alpha beta dimer
output	[Complex:R-RNO-2213212] alpha beta dimer:Ii trimer:calnexin [lumenal side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-RNO-2213239] Formation of MHC II alpha beta heterodimer - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2130478
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2132295] MHC class II antigen presentation
(precedingEvent)	[Reaction:R-RNO-2213241] Formation of nonameric complex
(inferredTo)	[Reaction:R-HSA-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer

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