Reactome | Interaction of invariant chain trimer and MHC II alpha beta dimer

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Interaction of invariant chain trimer and MHC II alpha beta dimer Show undefined attributes

authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
category	binding
compartment	[Compartment:5263265] lumenal side of endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:2130630] Garapati, P V, 2012-02-21
dbId	2130478
displayName	Interaction of invariant chain trimer and MHC II alpha beta dimer
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
eventOf	[Pathway:R-HSA-2132295] MHC class II antigen presentation - Homo sapiens
followingEvent	[Reaction:R-HSA-2213241] Formation of nonameric complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-195906] CANX [endoplasmic reticulum lumen] [Complex:R-HSA-2130599] Invariant chain trimer [lumenal side of endoplasmic reticulum membrane] [Complex:R-HSA-2213186] MHC II alpha beta heterodimer [lumenal side of endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2130436] Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain [LiteratureReference:2130307] Invariant chain transmembrane domain trimerization: a step in MHC class II assembly [LiteratureReference:2130535] Interaction of MHC class II molecules with the invariant chain: role of the invariant chain (81-90) region [LiteratureReference:2130510] Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding [LiteratureReference:2130526] Class II histocompatibility molecules associate with calnexin during assembly in the endoplasmic reticulum [LiteratureReference:2130319] A role for calnexin (IP90) in the assembly of class II MHC molecules [LiteratureReference:2230997] Invariant chain increases the half-life of MHC II by delaying endosomal maturation
maxDepth	1
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	Interaction of invariant chain trimer and MHC II alpha beta dimer
orthologousEvent	[Reaction:R-DRE-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer - Danio rerio [Reaction:R-SSC-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer - Sus scrofa [Reaction:R-BTA-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer - Bos taurus [Reaction:R-CFA-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer - Canis familiaris [Reaction:R-RNO-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer - Rattus norvegicus [Reaction:R-MMU-2130478] Interaction of invariant chain trimer and MHC II alpha beta dimer - Mus musculus
output	[Complex:R-HSA-2213212] alpha beta dimer:Ii trimer:calnexin [lumenal side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-2213239] Formation of MHC II alpha beta heterodimer - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2130478
summation	[Summation:2130631] MHC II alpha beta dimers associate with a third polypeptide,...

Referrals

(hasEvent)	[Pathway:R-HSA-2132295] MHC class II antigen presentation
(precedingEvent)	[Reaction:R-HSA-2213241] Formation of nonameric complex