Reactome | NF-kB is activated and signals survival

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NF-kB is activated and signals survival Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10223197
displayName	NF-kB is activated and signals survival
eventOf	[Pathway:R-RNO-193639] p75NTR signals via NF-kB - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-193703] IKKbeta is activated - Rattus norvegicus [Reaction:R-RNO-193705] IKKbeta phosphorylates IkB causing NF-kB to dissociate - Rattus norvegicus [Reaction:R-RNO-209536] IkB is ubiquitinated and degraded - Rattus norvegicus [Reaction:R-RNO-193691] NF-kB migrates to the nucleus and turns on transcription - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-209560] NF-kB is activated and signals survival - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	NF-kB is activated and signals survival
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-209560
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193639] p75NTR signals via NF-kB
(inferredTo)	[Pathway:R-HSA-209560] NF-kB is activated and signals survival

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