Reactome | Cell surface interactions at the vascular wall

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Cell surface interactions at the vascular wall Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222613
displayName	Cell surface interactions at the vascular wall
eventOf	[TopLevelPathway:R-RNO-109582] Hemostasis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:160572] leukocyte migration
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-202721] JAM2 binds JAM3 - Rattus norvegicus [Reaction:R-RNO-202706] Integrin alpha4beta1 binds JAM2:JAM3 - Rattus norvegicus [Reaction:R-RNO-9679740] ITGA4:ITGB1 binds natalizumab - Rattus norvegicus [Reaction:R-RNO-202726] F11R dimerises - Rattus norvegicus [Reaction:R-RNO-202718] Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) - Rattus norvegicus [Reaction:R-RNO-202704] Integrin alphaXbeta2 binds JAM3 - Rattus norvegicus [Reaction:R-RNO-202710] MERTK receptor binds ligands (Gas6 or Protein S) - Rattus norvegicus [Reaction:R-RNO-202713] CD84 homodimerises - Rattus norvegicus [Reaction:R-RNO-2870221] E-selectin binds E-selectin ligand - Rattus norvegicus [Reaction:R-RNO-202724] P-selectin binds P-selectin ligand - Rattus norvegicus [Reaction:R-RNO-202709] JAM2 dimerises - Rattus norvegicus [Reaction:R-RNO-202731] JAM3 dimerises - Rattus norvegicus [Reaction:R-RNO-202702] CD177 binds PECAM-1 - Rattus norvegicus [Reaction:R-RNO-202703] CD47 binds SIRP - Rattus norvegicus [Reaction:R-RNO-202722] CD48 binds CD244 - Rattus norvegicus [Reaction:R-RNO-202723] Integrin alpha5beta1 binds FN1 dimer - Rattus norvegicus [Reaction:R-RNO-199093] CXADR binds to AMICA1 - Rattus norvegicus [Reaction:R-RNO-141040] Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C - Rattus norvegicus [Reaction:R-RNO-203130] OLR1 binds to oxidized LDL - Rattus norvegicus [Reaction:R-RNO-203156] Platelet-derived TREM-1 ligand binds to TREM-1 - Rattus norvegicus [Pathway:R-RNO-210993] Tie2 Signaling - Rattus norvegicus [Pathway:R-RNO-210990] PECAM1 interactions - Rattus norvegicus [Pathway:R-RNO-210991] Basigin interactions - Rattus norvegicus [Reaction:R-RNO-202717] Heterodimerization of CEACAMs - Rattus norvegicus [Reaction:R-RNO-5676133] CD74 binds MIF - Rattus norvegicus [Reaction:R-RNO-8858428] FCAMR binds IgA - Rattus norvegicus [Reaction:R-RNO-8867240] EPCAM binds itself to form homotypic cell adhesion - Rattus norvegicus [Reaction:R-RNO-5635741] TRAIL receptor-4 binds TRAIL receptor-1 or TRAIL receptor-2 - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-202733] Cell surface interactions at the vascular wall - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Cell surface interactions at the vascular wall
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-202733
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-RNO-109582] Hemostasis
(hasEncapsulatedEvent)	[Pathway:R-RNO-5673001] RAF/MAP kinase cascade
(inferredTo)	[Pathway:R-HSA-202733] Cell surface interactions at the vascular wall

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