Reactome | CS/DS degradation

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CS/DS degradation Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224279
displayName	CS/DS degradation
eventOf	[Pathway:R-RNO-1793185] Chondroitin sulfate/dermatan sulfate metabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20683] proteoglycan catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-RNO-2022056] DSPG and CSPG translocate to the lysosome for degradation - Rattus norvegicus [Reaction:R-RNO-1606789] ARSB hydrolyses DS - Rattus norvegicus [Reaction:R-RNO-1793182] IDS hydrolyses dermatan sulfate (Chebi:63517 chain) - Rattus norvegicus [Reaction:R-RNO-2105001] HEXA cleaves the terminal GalNAc from DS - Rattus norvegicus [Reaction:R-RNO-9638075] HEXB cleaves the terminal GalNAc from DS - Rattus norvegicus [Reaction:R-RNO-1793186] IDUA hydrolyses the unsulfated alpha-L-iduronosidic link in DS - Rattus norvegicus [Reaction:R-RNO-1793207] ARSB hydrolyses C4S/C6S chains - Rattus norvegicus [Reaction:R-RNO-1793209] HYAL1-4 hydrolyze chondroitin chains - Rattus norvegicus [Reaction:R-RNO-1678854] GUSB tetramer hydrolyses CS/HS precursor - Rattus norvegicus [Reaction:R-RNO-2090079] GLB1 hydrolyses linker chain(2) - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-2024101] CS/DS degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	CS/DS degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2024101
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1793185] Chondroitin sulfate/dermatan sulfate metabolism
(hasEncapsulatedEvent)	[Pathway:R-RNO-2022923] DS-GAG biosynthesis [Pathway:R-RNO-2022870] CS-GAG biosynthesis
(inferredTo)	[Pathway:R-HSA-2024101] CS/DS degradation

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